Consensus guidelines on: screening, diagnosis and management of congenital hypothyroidism in Malaysia. Manual. Malaysian Endocrine and Metabolic Society (MEMS), Kuala Lumpur, Malaysia. (2021)
Abstract
Congenital hypothyroidism (CH) is the deficiency of thyroid hormone present at birth. It is the most common congenital endocrine disorder and is also the most common preventable cause of mental retardation in children1. In the majority of cases, the disorder is permanent and results from either an
abnormality in thyroid gland development (dysgenesis, agenesis or ectopia) or a defect in thyroid hormonogenesis. Less commonly, CH is transient and caused by transplacental passage of maternal anti-thyroid drugs, maternal thyrotropin receptor blocking antibodies, maternal or neonatal excessive
iodine exposure, low birth weight (LBW), and prematurity2. Transient CH usually resolves in the early months of infancy. Very rarely, CH results from a pituitary or hypothalamic abnormality (central or secondary/tertiary
hypothyroidism).
| Item Type: | Monograph (Manual) |
|---|---|
| Keywords: | Thyroid hormone, Congenital hypothyroidism, Hypothalamic Abnormality, Newborn babies, Child, Neurocognitive, Endocrine system |
| Taxonomy: | By Subject > Health Sciences > Nursing |
| Local Content Hub: | Subjects > Health Sciences |
| Depositing User: | Farleen Azrina Zamberi |
| Date Deposited: | 04 Jul 2022 08:04 |
| Last Modified: | 04 Jul 2022 08:04 |
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