Clinical practice guidelines: rational antibiotic utilisation in selected paediatric conditions. Manual. Health Technology Assessment Unit, Putrajaya, Malaysia. (2004)
Abstract
Febrile neutropenia is a common consequence of anticancer chemotherapy, fever being defined as a single oral temperature of more than or equal to 38.3°C with a neutrophil count of less than 500 cells/mm3 (Hughes et al, 1997, level 2). Cancer patients receiving myelosuppressive chemotherapy develop severe neutropenia and are at a high risk of developing life-threatening infections (Charnas, Luthi & Ruch, 1997, level 1; Cometta et al, 1996). Bacterial infections are a common cause of morbidity and mortality in
neutropenic cancer patients (Freifeld & Pizzo, 1997, level 9), with a microbiologic cause for the febrile episode being demonstrated in approximately 40% cases (Charnas, Luthi &
Ruch, 1997, level 1). These patients are at risk of endogenous flora, especially aerobic Gram-negative bacteria residing in the gastrointestinal tract and also those pathogens colonizing on normal or damaged mucosa or skin surfaces, like Gram-negative bacilli (Enterobacteriaceae, Klebsiella pneumoniae) or Gram-positive cocci (Staphylococcus aureus, Staphylococcus epidermidis and viridans streptococci) (Charnas, Luthi & Ruch, 1997, level 1; Patrick, 1997).
| Item Type: | Monograph (Manual) |
|---|---|
| Keywords: | Febrile neutropeni, Empiric antibiotic therapy, Anticancer chemotherapy, Treatment, Pediatric nursing |
| Taxonomy: | By Subject > Health Sciences > Nursing |
| Local Content Hub: | Subjects > Health Sciences |
| Depositing User: | Farleen Azrina Zamberi |
| Date Deposited: | 04 Jul 2022 08:36 |
| Last Modified: | 04 Jul 2022 08:36 |
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