Simulation of lovastatin production in solid-state fermentation via oil palm frond. Journal of Chemical Engineering and Industrial Biotechnology, 7 (2). pp. 7-10. ISSN 2600-7347 (2021)
Abstract
Lovastatin is a potent drug for lowering blood cholesterol. It is a competitive inhibitor of 3-hyroxy3-methyl glutaryl coenzyme A (HMG-CoA) reductase, which is a key enzyme in the cholesterol production pathway. Lovastatin increases good cholesterol or high-density lipoproteins to prevent the formation of plaque inside the blood vessels. This study aims to develop a process model of lovastatin produced by Meniscus purpureus under solid-state fermentation using oil palm frond. SuperPro Design V9.5 software was used to develop and simulate the process model. Three parameters which are initial moisture content, the composition of peptone and potassium, were varied to investigate their effects on lovastatin production. The optimum condition simulated using the process model at pH 7 with 60% initial moisture content, 0.0075 kg/hr of potassium and 0.0075 kg/hr of peptone was able to produce 0.0288 kg/kg of lovastatin. The simulated results show good agreement with experimental work, with a low percentage error of 5.77%, and provide a good approximation on lovastatin yield under various process operating conditions.
| Item Type: | Article |
|---|---|
| Keywords: | Lovastatin, Solid-state fermentation, SuperPro design, Simulation, Oil palm frond |
| Taxonomy: | By Subject > College of Engineering > Chemical Engineering > Biotechnology & Bioprocess By Subject > College of Engineering > Chemical Engineering > Oleochemical |
| Local Content Hub: | Subjects > College of Engineering |
| Depositing User: | Eza Eliana Abdul Wahid |
| Date Deposited: | 04 Aug 2022 09:01 |
| Last Modified: | 04 Aug 2022 09:01 |
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