Antidepressant and neuroprotective potential of stingless bee honey in a preclinical stress model. Antidepressant and neuroprotective potential of stingless bee honey in a preclinical stress model, 130. pp. 1-13. ISSN 106913 (2025)
Abstract
Stingless bee honey (SBH), as a functional food supplement, is of particular interest in this context due to its potential to modulate neurobiological factors such as BDNF and neurotransmitter release, which are often disrupted in depressive disorders. SBH is a fermented honey rich in trehalulose, probiotics, organic acids including aliphatic acids, and various bioactive compounds. These properties mitigate neurodegenerative processes by reducing oxidative stress and inflammation, enhancing neuronal resilience, and supporting the maintenance of cognitive function and overall brain health. This preclinical study aims to investigate the antidepressant effects of SBH in the chronic restrained stress (CRS) depression model via behavioural, hormone secretions, and histological analyses. Forty-two Swiss Albino mice (8 weeks old) were divided into five groups, receiving SBH supplementation or paroxetine (positive control). CRS was induced for 2 h daily for 28 days. The evaluated effects include body weight, behavioural tests, neurotransmitter levels, hippocampal neuron integrity, and brain-derived neurotrophic factor (BDNF) expression. The results of the physicochemical analysis confirmed that the SBH complied with the Malaysian Standard (MS2683:2017). FESEM experiment indicates the presence of bacteria and yeast on the walls of cerumen pots. Behavioural assessments demonstrated a significant reduction in anxiety-like behaviours and immobility duration among SBH-treated groups, indicative of its anxiolytic and antidepressant-like effects.
| Item Type: | Article |
|---|---|
| Keywords: | Stingless bee honey, Chronic restraint stress, Depression |
| Taxonomy: | By Niche > Kelulut (Stingless Bee) > Ecology By Niche > Kelulut (Stingless Bee) > Products Therapeutic Use By Niche > Kelulut (Stingless Bee) > Research |
| Local Content Hub: | Niche > Kelulut (Stingless Bee) |
| Depositing User: | Nor Azimahwati Aris |
| Date Deposited: | 17 Jul 2025 02:51 |
| Last Modified: | 17 Jul 2025 02:51 |
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