The Anti-Allergic Effects of Kelulut Honey Via The Regulation of Inflammatory Mediators of HMC-1 Cell. Masters thesis, Monash University Malaysia. (2021)
Abstract
Allergic diseases including anaphylaxis, asthma and atopic dermatitis are among the major chronic diseases across the world. During the early-phase of allergic reaction, the allergen-bound immunoglobulin E (IgE) crosslinks to the high-affinity IgE receptors (FcɛRI) on mast cell (MC) surface, leading to the activation of MC due to calcium ions (Ca2+) influx. Consequently, it activates the mitogen-activated protein kinases (MAPKs) and nuclear factor- κB (NF-κB) to promote transcription of pro-inflammatory mediators. The preformed and de novo synthesis of inflammatory mediators are then released to the extracellular environment through degranulation of MC which further contribute to the prolonged inflammatory response at the later phase. Kelulut
honey (KH) is a Malaysian honey produced by Trigona itama, which has been used as a remedy for wound healing and asthma in the past. Recently, scientific reports showed that KH is rich in phenolic acids and flavonoids which contribute to their antioxidant and anti-inflammatory properties
| Item Type: | Thesis (Masters) |
|---|---|
| Keywords: | Allergic, Kelulut honey, Inflammatory |
| Taxonomy: | By Niche > Kelulut (Stingless Bee) > Ecology By Niche > Kelulut (Stingless Bee) > Physiology By Niche > Kelulut (Stingless Bee) > Research |
| Local Content Hub: | Niche > Kelulut (Stingless Bee) |
| Depositing User: | Nor Azimahwati Aris |
| Date Deposited: | 27 Jun 2024 06:53 |
| Last Modified: | 27 Jun 2024 06:53 |
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