Potential Use of Zebrafish as Danon Disease Model: Comparative Computational Modeling and Protein-Protein Interaction Analysis on the LAMP2 Gene of Human, Mouse and Zebrafish. Malaysian Journal of Medicine and Health Sciences, 19 (SUPP7). pp. 85-86. ISSN 2636-9346 (2023)
Abstract
Danon disease is an X-linked dominant metabolic disorder, causes heart and skeletal muscle weakness, along with
intellectual disability. Mutations in lysosome-associated membrane protein 2 (LAMP2) are believed to cause the disease, which can be found in the lysosome membrane. This study performed computational homology modelling to
predict the protein structure of zebrafish LAMP2 to study the effect of LAMP2 gene mutations. The predicted LAMP2
protein structure was compared to human and mouse LAMP2 structures to assess the quality of the predicted protein
structure, and LAMP2 protein-protein interaction analysis was conducted. The findings support the use of zebrafish
as an animal model for Danon disease.
| Item Type: | Article |
|---|---|
| Keywords: | Danio Rerio, Zebrafish, Animal model, LAMP2, Danon disease, Gene mutations, Protein structure prediction |
| Taxonomy: | By Niche > Genome > Animal Genome Mapping By Niche > Genome > Human Genome Research |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 12 Jun 2024 08:56 |
| Last Modified: | 12 Jun 2024 08:56 |
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