Genetic analysis of a young adult presented with acute myocardial infarction with no traditional risk factors: a novel case report. Malaysian Journal of Medicine and Health Sciences, 18 (1). pp. 349-352. ISSN 2636-9346 (2022)
Abstract
Myocardial infarction (MI) in the young adults are more common among the Asians compared to the Caucasians.
It is of great interest to investigate the genetic risks that increase the susceptibility of MI in young patients with no
family history. We conducted a genetic analysis on a young adult diagnosed with acute MI. The coronary angiogram
showed acute complete occlusion of the left anterior descending artery with 40% left ventricular ejection fraction
(LVEF). Patient’s DNA was subjected to genotyping using Infinium Asian Screening Array. The genotypes were annotated and associated with risks of cardiovascular diseases catalogued in GWAS database. Ninety-four genetic variants were detected. Patient has more than half of the genetic variants being homozygous risk genotypes for coronary
artery and coronary heart diseases. Identifying the potential genetic modifiers associated with MI in young patients is
of great interest to help the clinician make informed decisions to implement preventive and personalised medicine
for this patient.
| Item Type: | Article |
|---|---|
| Keywords: | Young onset myocardial infarction, ST-elevation, Infinium asian screening array, Preventive and personalised medicine, Genetic variants, Coronary Artery Disease (CAD) |
| Taxonomy: | By Niche > Genome > Human Genome By Niche > Genome > Human Genome Research |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 12 Jun 2024 09:14 |
| Last Modified: | 12 Jun 2024 09:14 |
| Related URLs: |
Actions (login required)
 |
View Item |