Investigating the efficacy of gellan gum hydrogel films infused with Acacia stingless bee honey in wound healing. sciencedirect, 296. (2025)
Abstract
Effective wound healing requires biocompatible and functional wound dressings. This study explores the synergistic potential of gellan gum (GG), known for its exceptional gel-forming abilities, and acacia stingless bee
honey (SBH), for its potent antioxidant properties, in developing advanced wound care solutions. GG hydrogel
films incorporated with varying concentrations of SBH (v/v) at 10 % (GGSBH10), 15 % (GGSBH15), and 20 %
(GGSBH20) were characterized. The incorporation of SBH into the GG matrix resulted in distinctive spectral
peaks of ATR-FTIR associated with SBH, particularly evident in GGSBH20. Among the formulations, GGSBH20
demonstrated an impressive water vapor transmission rate of 1149 ± 11 g m− 2 d− 1 and a swelling ratio of 169 ±
7 %. Disk diffusion revealed that E. coli was susceptible to GGSBH. Cytotoxicity assessments (MTT and scratch
assays) on 3 T3-L1 cells confirmed the biocompatibility of GGSBH, which showed no cytotoxic effects up to 72 h
of incubation, and improved cell viability. Notably, GGSBH20 displayed the highest wound closure rate,
significantly enhancing cell migration and proliferation. Overall, our findings underscore the promising healing
properties of GG hydrogel films when enriched with acacia SBH, highlighting their potential as effective and
innovative wound dressing materials.
| Item Type: | Article |
|---|---|
| Keywords: | Wound dressing, Hydrogel film, Gellan gum, Stingless bee honey |
| Taxonomy: | By Niche > Kelulut (Stingless Bee) > Culture By Niche > Kelulut (Stingless Bee) > Ecology |
| Local Content Hub: | Niche > Kelulut (Stingless Bee) |
| Depositing User: | Nor Azimahwati Aris |
| Date Deposited: | 28 Apr 2025 03:58 |
| Last Modified: | 28 Apr 2025 03:58 |
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