Tumor Suppressive Effects of GAS5 in Cancer Cells. Non-Coding RNA, 8 (29). pp. 1-15. ISSN 2311-553X (2022)
Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility.
| Item Type: | Article |
|---|---|
| Keywords: | lncRNA, Growth-Arrest Specific Transcript 5, GAS5, Tumor Suppressor, Polymorphism |
| Taxonomy: | By Niche > Genome > Genomes By Niche > Genome > Human Genome |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 22 Jan 2025 01:52 |
| Last Modified: | 22 Jan 2025 01:52 |
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