Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee Trigona thoracica in mice. Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee Trigona thoracica in mice, 37. pp. 141-150. ISSN 2093-0569 (2024)
Abstract
Stingless bees are a monophyletic group of bees hibernating and pollinating in the tropical and subtropical regions [1,2]. They constitute about 500 species, known taxonomically as the family Apidae, and their most common genera are Trigona, including Trigona (Geniotrigona) thoracica [3]. Among products derived from stingless bees, propolis has been broadly used since ancient times as dietary supplementation, oral care products, creams, and ointments to enhance anti inflammatory, antimicrobial, antioxidant, and immunomodulatory activities [4–8]. In particular, previous studies have focused on pharmacological properties of the phenolic compounds predominantly present in propolis from the stingless bees [8–11]. Although non-steroidal anti inflammatory drugs (NSAIDs) and opioids have been the mainstream for anti-nociceptive analgesics in clinical practice [12,13], their use links to mild to severe adverse events from gastrointestinal disorder to psychologic addiction. Given that the naturally derived compounds from stingless bee’s propolis could be useful in various pharmacological activities, they have potential as new modern medicines, which could overcome adverse events from conventional analgesics. To date, the antinociceptive effects of propolis extracts from different species of bees have been studied in matters pertaining to accessible plants and cumulative evidence has reported analgesic effects of propolis from various regions [14–16]. Chinese propolis extracts from Poplar sp. (populus sp.) enriched with polyphenolic constituents presented antinociceptive activities, which could be attributed to their antioxidant effects [16]. Brazilian organic propolis from Apis mellifera suppressed the p38mitogen-activated protein kinase (MAPK) and p-JNK phosphorylation, as well as nuclear factor NF-κB activation in the murine macrophages cell line RAW264.7, suggesting its anti-inflammatory potential [17]. Furthermore, the antinociceptive activity of such propolis has been reported in animal models in the acetic acid-induced
abdominal constriction test, infrared hyperalgesia, and
formalin-induced paw licking test [14,15,18]. Stingless bees are geographically specified, becoming essential factors in explaining the variety of chemical compositions of propolis. However, to the best of the authors’ knowledge, no study has been carried out on the possible antinociceptive effects of propolis collected by Geniotrigona thoracica, since this species is an endemic species of stingless bee in Malaysia. Recent studies have revealed the pancreatoprotective and antimicrobial properties of propolis from Geniotrigona thoracica [19,20].
| Item Type: | Article |
|---|---|
| Keywords: | Analgesics, Bees, Caffeic Acid, Chromatography, Coumaric Acids, High Pressure Liquid, Nociceptive Pain, Pain Measurement, Polyphenols, Propolis |
| Taxonomy: | By Niche > Kelulut (Stingless Bee) > Ecology By Niche > Kelulut (Stingless Bee) > Products Therapeutic Use By Niche > Kelulut (Stingless Bee) > Research |
| Local Content Hub: | Niche > Kelulut (Stingless Bee) |
| Depositing User: | Ayuzawahie Amran |
| Date Deposited: | 12 Mar 2025 07:06 |
| Last Modified: | 12 Mar 2025 07:06 |
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