Evolutionary Genome Mining of the Human ACE2 Receptor and Spike Protein of SARS-CoV-2. Journal of Clinical and Health Sciences, 9. p. 21. ISSN 0127-984X (2024)
Abstract
INTRODUCTION: COVID-19 is a threat to global health as it has infected millions of
people with a wide spectrum of disease severity. Factors that contribute to this wide
spectrum include age, underlying medical conditions and genetic makeup. Genetic
factors are understudied with current available data often contradictory. This study
aims to investigate the effect of reported polymorphisms of ACE2 as well as mutations
in different variants of the constantly evolving SARS-CoV-2 against COVID-19
severity. Mutations that alter protein structure could affect the binding affinity of the
ACE2/SARS-CoV-2 interaction. An enhanced binding affinity could potentially
increase the initial viral load and potentially cause severe disease.
| Item Type: | Article |
|---|---|
| Keywords: | ACE2 Polymorphism, COVID-19, Genetic Variation, Genome Mining, SARS-CoV-2, Precision Health |
| Taxonomy: | By Niche > Genome > Human Genome By Niche > Genome > Human Genome Research By Niche > Genome > Viral Genomes |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 30 Apr 2025 09:09 |
| Last Modified: | 30 Apr 2025 09:09 |
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