Stingless Bee (Heterotrigona Itama) Honey and its Phenolic-Rich Extract Ameliorate Oxidant–Antioxidant Balance via KEAP1-NRF2 signalling pathway

Stingless Bee (Heterotrigona Itama) Honey and its Phenolic-Rich Extract Ameliorate Oxidant–Antioxidant Balance via KEAP1-NRF2 signalling pathway. National Library of Medicine, 15 (13): 2835. ISSN 2072-6643 (2023)



Abstract

Diabetes is associated with an imbalance between oxidants and antioxidants, leading to oxidative stress. This imbalance contributes to the development and progression of diabetic complications. Similarly, renal and liver diseases are characterised by oxidative stress, where an excess of oxidants overwhelms the antioxidant defense mechanisms, causing tissue damage and dysfunction. Restoring the oxidant–antioxidant balance is essential for mitigating oxidative stress-related damage under these conditions. In this current study, the efficacy of stingless bee honey (SBH) and its phenolic-rich extract (PRE) in controlling the oxidant–antioxidant balance in high-fat diet- and streptozotocin/nicotinamide-induced diabetic rats was investigated.

Item Type: Article
Keywords: stingless bee honey, phenolic-rich extract, oxidative stress
Taxonomy: By Niche > Kelulut (Stingless Bee) > Anatomy
By Niche > Kelulut (Stingless Bee) > Physiology
By Niche > Kelulut (Stingless Bee) > Research
Local Content Hub: Niche > Kelulut (Stingless Bee)
Depositing User: Nurmaisari binti Che Anuar (Kuala Terengganu)
Date Deposited: 27 Jun 2025 04:17
Last Modified: 27 Jun 2025 04:17
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