Unveiling the therapeutic potential of Kelulut (Stingless Bee) honey in Alzheimer’s Disease: findings from a rat model study. Antioxidants, 13 (8). ISSN 2076-3921 (2024)
Abstract
Alzheimer’s disease (AD) poses a major worldwide health challenge because of its profound impact on cognitive abilities and overall well-being. Despite extensive research and numerous clinical trials, therapeutic options remain limited. Our study aimed to investigate the potential of Kelulut honey (KH) as a novel therapeutic agent for addressing the multifactorial pathology of AD. We tried to evaluate the disease-attenuating and neuroprotective potential of KH in the intrahippocampally induced AD rat model by utilizing histochemistry and enzyme-linked immunosorbent assay (ELISA) studies. A total of 26 male Sprague Dawley rats weighing ~280–380 g were randomly divided into three groups: Control, AD-induced (Aβ), and AD-induced and treated with KH (Aβ+KH). The latter two groups underwent stereotaxic surgery, where 6.25 µg of amyloid β1–42 peptides were injected intrahippocampally. One-week post-surgery, KH was administered to the treatment group at a dose of 1 g/kg body weight for a period of four weeks, after which the rats went through behavior tests.
| Item Type: | Article |
|---|---|
| Keywords: | neurodegenerative disease, stingless bee honey, pot-honey, β-amyloid, neuroprotection |
| Taxonomy: | By Niche > Kelulut (Stingless Bee) > Breeding By Niche > Kelulut (Stingless Bee) > Diseases and Pests By Niche > Kelulut (Stingless Bee) > Research |
| Local Content Hub: | Niche > Kelulut (Stingless Bee) |
| Depositing User: | Nurmaisari binti Che Anuar (Kuala Terengganu) |
| Date Deposited: | 27 Jun 2025 04:16 |
| Last Modified: | 27 Jun 2025 04:16 |
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