Anti-cancer properties of heterotrigona itama sp. honey via induction of apoptosis in malignant glioma cells. Malaysian Journal of Medical Sciences (MJMS), 26 (2). pp. 30-39. ISSN 2180-4303 (2019)
Abstract
Background: There has been increasing evidence showing that stingless bee honey exhibits anti-oxidant, anti-inflammatory and anti-cancer properties. Pharmacologically-active components in honey such as flavonoids and phenolic constituents are known to contribute to its medicinal benefits. To the best of our knowledge, this is the first study on evaluating anticancer effects of locally-produced Malaysian stingless bee honey from Heterotrigona itama sp. on malignant glioma cells. Methods: Proliferation and apoptosis studies of U-87 MG cells following stingless bee honey treatment were carried out using MTS assay and acridine orange/propidium iodide dual staining, respectively. Results: Results demonstrated time and dose-dependent cytotoxicity using 0.625%, 1.25% and 10% stingless bee honey (P < 0.05). IC50 values were calculated using cells treated with 10% stingless bee honey. It was also observed that 10% stingless bee honey induced nuclear shrinkage, chromatin condensation and nucleus fragmentation, indicating that cellular changes were consistent with the apoptotic characteristics of the cells.
| Item Type: | Article |
|---|---|
| Keywords: | Malignant glioma, Stingless bee, Heterotrigona itama, Apoptosis, Anti-cancer, Anti-oxidant, Madu kelulut |
| Taxonomy: | By Subject > Applied Sciences > Biology By Subject > Applied Sciences > Food Technology |
| Local Content Hub: | Subjects > Applied Sciences |
| Depositing User: | Rizana Mohd Radwan |
| Date Deposited: | 10 Mar 2021 13:53 |
| Last Modified: | 10 Mar 2021 13:53 |
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