Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study. Malaysian Journal of Medicine and Health Sciences, 17 (3). pp. 55-62. ISSN 2636-9346 (2021)
Abstract
Introduction: This cohort aimed to determine glycemia distribution of pregnant women and maternal glycemia categories and its correlation with adverse pregnancy outcomes among Malaysian women.
Methods: A retrospective cohort study of normal glycemia pregnant women. Binary logistic regression was used to examine the associationsbetween maternal glycemia categories and adverse outcomes.
Results: Women with elevated fasting plasma glucose(FPG) were at lower risk of having SGA infants (aORFPG 4= 0.64, 95% CI= 0.47 – 0.85; aORFPG 6= 0.68, 95% CI= 0.43–0.98; aORFPG 7= 0.64, 95% CI= 0.42–0.96) than those women in category 1. Women in the higher 2-hour plasma glucose (2hPG) category had a nearly two-fold risk of having LBW and LGA infants. Hyperglycemia less severe than gestational diabetes mellitus (GDM) was associated with LGA (aOR= 1.22, 95% CI= 1.07 – 1.88) and caesarean delivery (aOR= 1.80, 95% CI= 1.20 – 2.69), in the meanwhile GDM was associated with caesarean delivery (aOR= 1.33, 95% CI= 1.02 –1.79).
Conclusion: Cut-off points for FPG and 2hPG that relate to adverse pregnancy outcomes started at 4.9 – 5.0 mmol/l and 7.5 – 7.7 mmol/l. These cut-off points were lower than the current recommended criteria of Clinical Practice Guideline (CPG) of Malaysia for GDM diagnosis. Large-scale studies are required to identify the optimal GDM cut-off.
| Item Type: | Article |
|---|---|
| Keywords: | Pregnancy outcomes, Maternal glycemia, Gestational diabetes mellitus, Hyperglycemia |
| Taxonomy: | By Subject > Medicine > Endocrine System By Subject > Medicine > Gynecology |
| Local Content Hub: | Subjects > Medicine |
| Depositing User: | Adi Azri Mohamad (Sg. Buloh) |
| Date Deposited: | 08 Oct 2021 23:54 |
| Last Modified: | 14 Oct 2021 07:46 |
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