Bacterial secondary metabolite activation through epigenetic modifiers: a systematic review. Science & Technology, 32 (2). pp. 495-507. ISSN 2231-8526 (2024)
Abstract
Bacteria have produced many important secondary metabolites, especially in the pharmaceutical industry. However, the increase in the rediscovery rate of the known
compound has been inconvenient to researchers and the pharmaceutical industry. Nevertheless, genome mining in bacteria has uncovered several cryptic metabolic pathways
that may be key to discovering new secondary metabolites. The conventional laboratory environment, however, limits the metabolic pathways of microorganisms, making it impossible for secondary metabolites to be produced. As a result, researchers began using epigenetics to change the expression of the genes that code for secondary metabolites in microorganisms. Using epigenetics modifiers, secondary metabolite gene clusters are activated without altering the bacterial DNA sequence. This review article focuses on
the different epigenetic changes and how they affect gene expression to activate the synthesis of secondary metabolites in bacteria.
| Item Type: | Article |
|---|---|
| Keywords: | Bacterial, Epigenetic Modifiers, Gene Clusters, Secondary Metabolites |
| Taxonomy: | By Niche > Genome > Bacterial Genomes |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 01 Oct 2025 08:41 |
| Last Modified: | 01 Oct 2025 08:41 |
| Related URLs: |
Actions (login required)
 |
View Item |