Mat Jaya, Norshahida and Muhammad Low, Anis Low and Ariffi, Suhaidi and Khaidir, Siti Solihah and Bahron, Hadariah and Ismail, Nor Hadiani and Syed Mohamad, Sharifah Aminah Screening of schiff base ligands derived from Phenylenediamine and its metal complexes as a potential efflux pump inhibitor against K. Pneumoniae. 1st ed. Asian Federation of Biotechnology, Universiti Putra Malaysia. ISBN 9789671727119 (2021)
Abstract
Treatment of infectious diseases is becoming more complex and ineffective as the rate of multidrug resistance (MDR) bacteria rises. Schiff base is synthesized from condensation reaction of primary amines with active carbonyl compounds and considered as “privileged ligands” because of their coordination with many different metals and able to stabilize metals in various oxidation states. These compounds have showed promising antibacterial agents but their potential as efflux pump inhibitor in bacterial resistance mechanism is still limited. This study focusses on the screening of 40 Schiff base compounds that consist of ligands and metal complexes as efflux pump inhibitor against K. pneumoniae by resazurin microtiter-based assay using nalidixic acid and chloramphenicol as antibiotics at their subMIC concentrations. It was found that, Co4[OVan(Me)MPD] displayed the highest inhibition at 86.5% when Schiff base compounds and K. pneumoniae ATCC 700603 were treated with sub-MIC of chloramphenicol (20 µg/mL). Metal of copper exhibits the highest activity than other metal complexes and this agree with Overton’s and Tweedy’s chelation theory, where metal complexes have better potential as antibacterial agents than their parent ligands. As a conclusion, unique tetranuclear complexes possess potential for future development as efflux pump inhibitors.
| Item Type: | Book |
|---|---|
| Keywords: | Schiff Base, Efflux Pump Inhibitor, K. penumoniae, Bacterial Resistance |
| Taxonomy: | By Niche > Genome > Bacterial Genomes By Niche > Genome > Genomes |
| Local Content Hub: | Niche > Genome |
| Depositing User: | Hazrul Amir Tomyang (Puncak Alam) |
| Date Deposited: | 15 Dec 2025 06:40 |
| Last Modified: | 15 Dec 2025 06:40 |
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