Psychiatric Manifestations in Orthopedic Patients on Celecoxib Therapy

Psychiatric Manifestations in Orthopedic Patients on Celecoxib Therapy. Malaysian Journal of Medicine and Health Sciences, 6 (2). pp. 41-42. ISSN 2636 - 9346 (2010)


Introduction: The Cyclooxygenase-2 (COX-2) enzyme is responsible for the synthesis of prostaglandin which is responsible for inflammation and pain. Celecoxib a cyclooxygenase-2 inhibitor was first used as a non-steroidal anti-inflammatory drug in 1999. Celecoxib is as effective as NSAIDs but causes less ulceration of the gastrointestinal tract, hence it is commonly used. It has been widely used in patients with osteoarthritis and rheumatoid arthritis. We present 3 cases of temporary psychiatric disorders associated with consumption of celecoxib, two of the patients presented with auditory hallucinations while one was diagnosed to be having depression. None had pre-existing psychiatric disorders or consumed alcohol or substance of abuse. All 3 patients recovered from their temporary psychiatric disorders after stopping celecoxib.

Discussion: It is important to be aware of the psychiatric side effects when prescribing the drug for prolonged periods.

Item Type: Article
Keywords: Celecoxib, cyclooxygenase-2, psychotic disorder, drug, hallucinations, depression
Taxonomy: By Subject > Medicine > Rehabilitation Medicine
Local Content Hub: Subjects > Medicine
Depositing User: Adi Azri Mohamad (Sg. Buloh)
Date Deposited: 11 Oct 2021 23:38
Last Modified: 11 Oct 2021 23:38
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